Tumor acidosis refers to the acidic microenvironment that is often present within solid tumors. This acidosis is caused by the metabolic activity of rapidly proliferating cancer cells, which produce high levels of lactic acid as a byproduct of anaerobic glycolysis. The acidic pH of the tumor microenvironment can have significant impacts on various aspects of tumor growth and progression, including promoting invasion, metastasis, and resistance to therapy. Researchers studying tumor acidosis aim to understand the mechanisms by which acidosis influences tumor behavior and to identify potential therapeutic targets for disrupting the acidic microenvironment and improving treatment outcomes for cancer patients. This research area involves a multidisciplinary approach that may include studies on cell metabolism, signaling pathways, and interactions between cancer cells and the surrounding stromal cells in the tumor microenvironment.